Quality by Design: Optimization of Letrozole Solid Lipid Nanoparticle for Breast Cancer

Abstract: Aim: Hormone responsive breast cancer is the most prevalent worldwide. Letrozole a third-generation aromatase inhibitor widely used for treatment of advanced cancer. The primary objective present work to develop and optimize an injectable solid lipid nanoparticle incorporating letrozole circumvent side-effects marketed conventional formulation thereby improve patient compliance. Materials Methods: Emulsification solvent evaporation melt dispersion techniques were formulating said nanoparticles. Quality by design concept was development optimization process variables. Results: optimum level selected 60 mg lipid, 30 surfactant, co-surfactant, 15000 psi HPH pressure, 15 passes. Conclusion: Glyceryl dibehenate as suitable based on solubility partition coefficient. With increase in content there particle size PDI decrease entrapment efficiency. Higher surfactant co-surfactant concentrations result lower size, PDI, higher zeta potential, An pressure reduced up certain level, however, from 20000 increased size. number passes reduces PDI. drug release mechanism LTR-SLN found follow first order higuichi model. Keywords: Solid nanoparticle, Letrozole, Ishikawa diagram, Plackett burman design, Central composite Mathematical modeling.